Kudala, abantu bezibuza ukuba kutheni isifo semithambo-luvo sinje oomatshini bokuzenzekelayoNgamanye amagama, ukukhula kwayo kwabanye abantu hayi kwabanye, kwaye ngaphezu kwako konke, kunokufezekiswa njani kungekuphela nje ukuba olu hlobo lwesifo aluphuhlisi, kodwa nokuba abantu abachaphazelekayo banokuphilisa. Enkosi kuphando olutsha olusandula kukubona ukukhanya, kubonakala ngathi sisondele kakhulu ekufezekiseni mhlawumbi ukungaphilisi abantu abane-autistic, kodwa endaweni yoko yifumane ekuphuhliseni kwiimeko ezininzi.
Phambi kokumilisela iintsimbi kwinqwelomoya, njengoko zihlala zisenzeka ngolu hlobo lweprojekthi, inyani kukuba sijamelene nophando oluthi, nangona lufumene impumelelo engenakuphikwa, isenendlela ende ekusafuneka ihanjiwe, ngakumbi ukuba sithathela ingqalelo into yokuba, njengoko kubonisiwe ngabo banoxanduva, sithetha ngoguquko lwemfuza oluguqula ukwakheka kwee-neuron, oko ke kubangele ukubonakala kwe-autism.
Ndiyabulela kolu phando siyazi ukuba utshintsho kwi-GRIN2B yemfuza sesinye sezizathu ezibangela i-autism
Kule projekthi, abaphandi ababandakanyekayo kuyo banomdla kakhulu ekuziphatheni kohlobo olwaziwa ukuba lubangela i-autism xa isiya kuguquka. Sithetha ngokukodwa malunga nofuzo I-GRIN2B, ebaluleke kakhulu kunxibelelwano phakathi kwee-neurons ezivuthiweyo kwaye yaziwa njengenxalenye yenye yezona zinto zibalulekileyo zifumanekayo kwingqondo yomntu.
Ukwenza oku kufunyanisiweyo, bebesebenza kwiiseli zolusu zesigulana. Nje ukuba kukhutshwe, ezi seli zazikho yenziwa ngokutsha ngobunjineli bemfuza ukuze itshintshe ibe ziiseli zobuchopho. Ngombulelo kulo msebenzi ubalaseleyo, kuye kwabakho ukumisela ukuba iseli yengqondo ethwele njani uguquko oluthile kwimfuza yesigulana esine-autistic sikhule ngendlela engaqhelekanga.
Ukuya kwinkcukacha ezithe kratya, kubonakala ngathi abaphandi, ngexesha lomsebenzi wabo waselebhu, bekwazile ukufumanisa ukuba i-GRIN2B, ukongeza ekubeni nolwalamano oluthile nee-neurons ezivuthiweyo, ikwayinto ebaluleke kakhulu kwimfuza ngexesha lokwenziwa kweeseli zemithambo-luvo, ngokuchanekileyo ikwafanayo apho kwenziwa ii-neurons.
Nje ukuba sicace gca kule ndawo, kulula ngakumbi ukuyiqonda into yokuba utshintsho olwenziweyo kwi-GRIN2B gene inoxanduva lokudala iprotein ethi, kuvavanyo olwenziwe elebhu, kujike kube yiyo inoxanduva lweeseli zeziqu ezivelisa iprotein efanayo engundoqo kumanqanaba okuqala ophuhliso lwe-autism. Nje ukuba oku kufunyaniswe, izazinzulu ziye zakwazi ukulungisa, elabhoratri, oku kuguquka kwemfuza ngokubangela ukuba iiseli zemithambo-luvo ezichaphazelekayo zibe sempilweni kwaye zingabangeli i-autism.
Inyaniso yokuba uguquko lwe-GRIN2B inokubangela i-autism ayizichasanga ezinye izizathu ezinokubakho
Ngaphandle kwamathandabuzo, le projekthi ivula iingcango ezintsha kuphando lwexesha elizayo ukusukela, kwelinye icala nanjengoko uluntu lubhengeza, akuzange kubekho liqela lezenzululwazi eliye laya kufunda ngezizathu ezivela kwi-autism, ngelixa kwelinye icala le projekthi inika yemfuza indima efanelekileyo kwimvelaphi yesi sifo. Kuyinyani ayiziphelisi ezinye izizathu ezinokubakho, kodwa isivumele ukuba siqinisekise ukuba utshintsho kwimfuza lukhokelela ekubonakalisweni kwe-autism ebantwini.
Elinye inqaku elibalulekileyo lale projekthi kukuba, ngokuchasene nolingo lwangaphambili kunye nofuzo lwe-GRIN2B olwaluphuhliswe ikakhulu kwiintonga, iiseli zomntu zisetyenziswe okokuqala, into leyo, njengoko iqinisekisiwe luluntu ngokwalo, Ibeka umbono omtsha ngokupheleleyo kuhlobo lwesi sifo.
Njengoko unokucinga, kusekho indlela ende ekufuneka yenziwe kude kube abantu banokuphelisa i-autism kodwa, enkosi kule projekthi, abo basaphuhlayo namhlanje kwaye ngakumbi imisebenzi engekazukubakho, sisondele ngakumbi ukuyenza yenzeke.
Ndinomfana oneminyaka emi-5 ubudala kwaye andinakuyitshintsha okanye i-autism yayo nantoni na apha emhlabeni. Inokhetho lwayo, amandla ayo kunye nobuthathaka bayo. Uxanduva lwawo nawuphi na umzali kukulwa ukuze amanqaku abo abuthathaka anciphe. Kodwa ukuthetha ngokupheliswa kwe-autism kubonakala ngathi kuyaphazamiseka kum. I-Autistics ngabantu ababona umhlaba ngendlela eyahlukileyo, kodwa ngubani onokusiqinisekisa ukuba yeyiphi indlela eyiyo yokuphila kunye nokubona umhlaba? Mhlawumbi zi-blondes kuphela ekufuneka ziphile kwaye ezinye mazitshatyalaliswe? okanye kuphela abo baphumelelayo kwizibalo njl. ukusoloko ndithetha nge-autism ngokungathi sisifo, ukuthatha abantwana kunyango olungummangaliso, ukuphupha malunga neepilisi ezikubuyisela umntwana osoloko uphupha ngaye kubonakala kum njengembono ephosakeleyo. Uxanduva lwawo nawuphi na umzali kukuba abantwana babo bonwabe kwaye yile nto kufuneka ijongiwe kwaye yeyokulwela ngamaxesha onke.