Nangona kukhangeleka ngathi zonke izazinzulu zifuna, ngandlela thile, ukukhokela amakhondo emisebenzi ukufezekisa isiphelo esinqwenelekayo sokunyanga umhlaza, inyani kukuba zininzi izifo ezithi ngelishwa zenzakalise nabantu abaninzi abanjengesifo seswekile.
Kulo IYunivesithi yaseLancaster (I-United Kingdom) ineqela elipheleleyo labaphandi abasebenza kuphuhliso lwamachiza amatsha anakho, ngokuchanekileyo, okuphilisa isifo seswekile. Kuyabonakala kwaye njengoko kutyhiliwe, ngelixa besebenza kuphuhliso lwemveliso entsha ngokuchasene nohlobo lwesibini lweswekile, bafumene isisombululo inokunyanga i-Alzheimer's.
Eli yeza kunyanga uhlobo lwesifo seswekile linokusetyenziswa njengeyeza le-Alzheimer's
Ngenxa ye 'ziphose iintsimbi ukuba zibhabhe'okanye nayiphi na into elolo hlobo, xelela ukuba, kuba sithetha ngovavanyo lwelabhoratri, inyani kukuba okwangoku ekuphela kwento esele ifezekisiwe kukwenza iyeza elinakho ukubuyisela umva ukulahleka kwememori kwiimpukuUkuqala ukuvavanya ebantwini, usemninzi umsebenzi ekufuneka wenziwe, ke ukuze le mveliso ifike kwintengiso, sisenokuthetha ngeminyaka.
Inyaniso ke kukuba thina Inyathelo elinye ukusondela ekufumaneni unyango lwesifo esifana ne-Alzheimer's, Esinye sezifo ze-neurodeergenerative zezifo, ngokwezifundo zamva nje ezenziwa ngeendlela ezahlukeneyo, ziye zanda kakhulu, ngakumbi kumazwe aseNtshona. Inyani ebaluleke kakhulu kukuba, ngelixa ngo-2015 zazingama-48 ezigidi izigulo zesifo sengqondo esixhalabisayo kwihlabathi jikelele, namhlanje zizigidi ezisi-7.5 iziganeko ezithe zafunyaniswa nyaka ngamnye.
Ngale nto engqondweni, ayimangalisi into yokuba, ngokokutsho kwabasemagunyeni kwezempilo, i-Alzheimer iye yadweliswa njengeyona nto ixhaphakileyo kwisifo sengqondo esixhalabisayo ukusukela, namhlanje, inezigulana ezingaphezulu kwezigidi ezingama-30, inani elingathi, ngokwe-WHO uqobo, zikhule ziye kuma-53 eziganeko ezifunyenwe kwiminyaka engama-30 kuphela.
Yintoni i-Alzheimer's kwaye yenzeka njani?
Ngokutsho kweengcali, i-Alzheimer's kubonakala ngathi yenzekile ngenxa Ukuqokelelwa okungaqhelekanga kakhulu kweeproteni ze-beta amyloid kunye ne-tau kwingqondo yomntu. Olu qokelelo lubangela ukuvela kweetangles ze-neurofibrillary kunye neeplathi ezinobuthi ezinobungozi, into ethi ekugqibeleni ikhokelele kumonakalo omkhulu ekusebenzeni kakuhle kwengqondo.
Ukubuyela kwiprojekthi ephuhliswe ngabaphandi kwiYunivesithi yaseLancaster, kubonakala ngathi uhlobo lwesifo seswekile sesifo sesifo seswekile sesona sifo sinomngcipheko omkhulu wokugula sisifo i-Alzheimer's, yona, inxulumene ngokusondeleyo nokuqhubela phambili kwesi sifo. Kungenxa yokuba, ukungakwazi ukuvelisa okanye ukusebenzisa i-insulin inxibelelene ngqo nenkqubo yokwehla kwengqondo kwingqondo yomguli exhaphake kuzo zombini iimeko.
Eli chiza liyakwazi ukukhusela ingqondo yesigulana ngeendlela ezahlukeneyo
Njengoko kuchaziwe ngu UGqr. Doug Brown, UMlawuli woPhando noPhuhliso loMbutho we-Alzheimer's:
Ngaphandle konyango olutsha phantse kwiminyaka eli-15, kufuneka sifumane iindlela ezintsha zokulwa i-Alzheimer's. Kubalulekile ukuba sihlolisise ukuba ngaba amayeza aphuhlisiwe ukunyanga ezinye iimeko anokunceda abantu abane-Alzheimer's kunye nezinye iintlobo zesifo sengqondo esixhalabisayo. Le ndlela yophando inokwenza ukuba ikhawuleze kakhulu ukufumana amachiza amatsha athembisayo kubantu abawadingayo.
Ukuvavanya olu hlobo lwesisombululo, iqela labaphandi elijongene nophuhliso lweprojekthi lisebenzise i-APP / PS1 iimpuku. Olu hlobo lweempuku ze-transgenic, sithetha ngohlobo lwempuku evakalisa imizila yemfuza yomntu ejongene nesifo se-Alzheimer's. Phakathi kweemvavanyo ezenziweyo, kufanele ukuba kuqatshelwe ukuba izilwanyana ezincinci zanyangwa ngechiza elinomsebenzi «kathathu i-agonist»Ngubani obonise ukuba unayo ukukwazi ukukhusela ingqondo ngeendlela ezahlukeneyo: ukuphucula ukufunda nokwakhiwa kwememori, ukukhusela iiseli zemithambo-luvo, ukunciphisa inani lamacwecwe e-amyloid, ukunciphisa ukudumba okungapheliyo kunye noxinzelelo lwe-oxidative, kunye nokucothisa ilahleko yeeseli zemithambo-luvo.
Más información: IYunivesithi yaseLancaster