Sekuyisikhathi eside umuntu ezibuza ukuthi kungani ukuphazamiseka kwemizwa njengoku automatism, okungukuthi, ikhula kanjani kwabanye abantu hhayi kwabanye, futhi ngaphezu kwakho konke, ingafinyelelwa kanjani hhayi kuphela ukuthi lolu hlobo lokuphazamiseka aluveli, kepha nokuthi abantu abathintekile bangalulama. Ngenxa yocwaningo olusha olusanda kubona ukukhanya, kubonakala sengathi sisondele kancane ekufinyeleleni mhlawumbe hhayi ekwelapheni abantu abane-autistic, kodwa kunalokho ithole ukuthi ingakhuli ezimeni eziningi.
Ngaphambi kokwethula izinsimbi endizeni, njengoba kuvame ukwenzeka ngalolu hlobo lwephrojekthi, iqiniso ukuthi sibhekene nophenyo lokuthi, yize luthole impumelelo engenakuphikwa, luselude ukhalo okusamele luhambe, ikakhulukazi uma sibheka ukuthi, njengoba kukhonjisiwe yilabo abanomthwalo wemfanelo, sikhuluma ngokuguquka kwezakhi zofuzo okuguqula ukwakheka kwama-neuron, ngaleyo ndlela kubangele ukuvela kwe-autism.
Ngenxa yalolu cwaningo siyazi ukuthi uguquko kuhlobo lwe-GRIN2B lungezinye zezimbangela ze-autism
Kule phrojekthi abacwaningi ababambe iqhaza kuyo babe nentshisekelo enkulu ekuziphatheni kofuzo olwaziwa ukudala i-autism lapho luguquka. Sikhuluma ngokukhethekile ngofuzo I-GRIN2B, ebaluleke kakhulu ekuxhumaneni phakathi kwama-neurons avuthiwe futhi yaziwa njengengxenye yesinye sezamukeli ezibaluleke kakhulu ezikhona ebuchosheni bomuntu.
Ukwenza lokhu okutholakele, bebesebenza kumaseli wesikhumba esiguli. Uma esekhishiwe, lawa maseli ayesele yenziwe kabusha ngobunjiniyela bokuguqula amaseli obuchopho. Ngenxa yalo msebenzi omangalisayo, bekwenzeka ukunquma ukuthi ingqamuzana lobuchopho elithwala ukuguqulwa okuthile kofuzo lwesiguli esine-autistic likhule kanjani ngendlela engajwayelekile.
Ukungena emininingwaneni ethe xaxa, kubonakala sengathi abacwaningi, ngesikhathi somsebenzi wabo waselebhu, bakwazile ukubona ukuthi i-GRIN2B, ngaphezu kokuba nobudlelwano obuthile nama-neurons avuthiwe, nayo yayiyi isakhi sofuzo esibaluleke kakhulu ngesikhathi kwakhiwa amangqamuzana ama-neural stem, ngokufana ncamashi lapho kwakhiwa khona ama-neurons.
Lapho sesicacile kule ngxenye, kuba lula kakhulu ukuqonda ukuthi ukuguquka kwesakhi sofuzo ku-GRIN2B kunesibopho sokwakha iphrotheni, ekuhlolweni okwenziwe elabhoratri, okwaba yilo obhekele ama-stem cells akhiqiza amaprotheni afanayo ayisihluthulelo ezigabeni zokuqala zokuthuthukiswa kwe-autism. Lapho lokhu sekutholakele, ososayensi bakwazi ngisho ukulungisa, elabhorethri, lokhu kuguqulwa kofuzo ngokwenza amaseli we-neural stem athintekayo aphile futhi angabangeli i-autism.
Iqiniso lokuthi ukuguqulwa kwe-GRIN2B kungadala i-autism aliziphikisi ezinye izimbangela ezingaba khona
Akungabazeki ukuthi, le phrojekthi ivula iminyango emisha ocwaningweni lwesikhathi esizayo ngoba, ngakolunye uhlangothi futhi njengoba umphakathi umemezela, alikaze kube nethimba lososayensi elihambe ibanga elide kangaka ekutadisheni izizathu eziqala i-autism ngenkathi ngakolunye uhlangothi, le The project inika izakhi zofuzo indima efanelekile kumsuka walesi sifo. Kuyiqiniso lokho ayiziqedi ezinye izimbangela ezingaba khona, kodwa kusivumele ukuthi siqinisekise ukuthi ukuguquka kwezakhi zofuzo kuholela ekubonakalisweni kwe-autism kubantu.
Elinye iphuzu elibalulekile lale phrojekthi ukuthi, ngokungafani nokuhlolwa kwangaphambilini kofuzo lwe-GRIN2B olwenziwe ikakhulukazi kumagundane, amaseli womuntu asetshenziswe okokuqala, into, njengoba kuqinisekisiwe ngumphakathi wesayensi uqobo, iveza umbono omusha ngokuphelele ngofuzo lwalesi sifo.
Njengoba kungenzeka ucabanga, luselude ukhalo okusamele luhanjwe kuze kube yilapho abantu bengaqeda i-autism kodwa, ngenxa yale phrojekthi, labo abasathuthuka namuhla futhi ikakhulukazi imisebenzi engakabi khona, sisondele eduze ukuyenza kwenzeke.
Nginomfana oneminyaka engu-5 ubudala one-autistic futhi iqiniso ukuthi ngeke ngimshintshe noma i-autism yakhe nganoma yini emhlabeni. Inezintandokazi zayo, amandla ayo nobuthakathaka bayo. Isibopho sanoma imuphi umzali ukulwa ukuze amaphuzu abo abuthakathaka anciphe ngokuncipha. Kepha ukukhuluma ngokuqedwa kwe-autism kubonakala kungahambi kahle kimi. Ukuzenzela izinto ngabantu ababona umhlaba ngenye indlela, kepha ngubani ongasiqinisekisa ukuthi iyiphi indlela efanele yokuphila nokubona umhlaba? Mhlawumbe ama-blondes kuphela okufanele aphile kanti amanye kufanele aqedwe? noma kuphela labo abenza kahle ezibalweni njll. ukukhuluma njalo nge-autism njengokungathi kuyisifo, ukuyisa izingane ekwelashweni okuyisimangaliso, ukuphupha ngamaphilisi akubuyisela ingane okade uyiphupha kubonakala kimi kungumbono ongalungile impela. Isibopho sanoma yimuphi umzali ukuthi izingane zakhe zijabule futhi yilokho okufanele zikufune nokuthi yini okufanele zikulwele ngaso sonke isikhathi.