Yize kubonakala sengathi bonke ososayensi bafuna, ngandlela thile, ukuqondisa imikhakha yabo ukuze bafeze injongo abayifunayo yokwelapha umdlavuza, iqiniso ukuthi kunezifo eziningi ngeshwa ezilimaza ngisho nabantu abaningi abanjengesifo sikashukela.
Ku ILancaster University (E-United Kingdom) kuneqembu eliphelele labaphenyi abasebenza ekwakheni imishanguzo emisha ekwazi ukwelapha isifo sikashukela. Ngokusobala futhi njengoba sekuveziwe, ngenkathi besebenza ekwakhiweni komkhiqizo omusha olwa nohlobo 2 lwesifo sikashukela, bathole isisombululo izosebenza ukwelapha i-Alzheimer's.
Lo muthi wokwelapha isifo sikashukela sohlobo lwe-2 ungasetshenziswa njengekhambi le-Alzheimer's
Ngaphambi kwe 'phonsa izinsimbi ukuze ubaleke'noma yini efana naleyo, ngikutshele ukuthi, njengoba sikhuluma ngokuhlolwa kwelabhorethri, iqiniso ukuthi okwamanje okuwukuphela kwento esezuziwe ukudala umuthi okwazi buyisela emuva kakhulu ukulahleka kwememori kumagundaneUkuqala ukuhlola nabantu, usemningi umsebenzi okumele wenziwe, ngakho-ke ukuze lo mkhiqizo ufike emakethe, sisengakhuluma ngeminyaka.
Okungenani, iqiniso ukuthi singuye isinyathelo esisodwa esiseduze nokuthola ikhambi lesifo esinjenge-Alzheimer's, esinye salezo zifo ezingenayo i-neurodegenerative, ngokwezifundo zakamuva ezenziwa ngezindlela ezahlukahlukene, ezikhule kakhulu, ikakhulukazi emazweni aseNtshonalanga. Iqiniso elibaluleke kakhulu ukuthi, ngenkathi ngo-2015 kwakukhona izigameko eziyizigidi ezingama-48 zokuwohloka komqondo emhlabeni jikelele, namuhla kunamacala angaphezu kwezigidi eziyi-7.5 atholakala unyaka ngamunye.
Unalokhu engqondweni, akumangazi ukuthi, ngokusho kweziphathimandla zezempilo, i-Alzheimer's ibalwe njengesizathu esivame kakhulu sokuwohloka komqondo kusukela, namuhla, ineziguli ezingaphezu kwezigidi ezingama-30, isibalo, ngokusho kwe-WHO uqobo, zikhule zibe namacala ayizigidi ezingama-53 atholakala eminyakeni engama-30 kuphela.
Yini i-Alzheimer's futhi kwenzeka kanjani?
Ngokusho kochwepheshe, i-Alzheimer's ibonakala idalwa yi ukuqongelela okungajwayelekile kakhulu kwamaprotheni e-beta amyloid kanye ne-tau ebuchosheni bomuntu. Lokhu kunqwabelana kubangela ukuguqulwa kwamathambo we-neurofibrillary namacwecwe anobuthi obunobuthi, okugcina kugcina kulimaze kakhulu ukusebenza okufanele kobuchopho.
Ukubuyela kuphrojekthi eyenziwe ngabacwaningi e-University of Lancaster, kubonakala sengathi uhlobo lwesifo sikashukela esingu-2 luyingozi enkulu yokuhlushwa yi-Alzheimer's, nayo, ehlobene kakhulu nokuqhubekela phambili kwalesi sifo. Lokhu kungenxa yokuthi, ukungakwazi ukukhiqiza noma ukusebenzisa i-insulin ixhunyaniswe ngqo nenqubo yokonakala ebuchosheni besiguli evamile kuzo zombili izimo.
Lesi sidakamizwa sikwazi ukuvikela ubuchopho besiguli ngezindlela ezihlukile
Njengoba kuchazwe yi- UDkt. Doug Brown, Umqondisi Wezocwaningo Nentuthuko Ye-Alzheimer's Society:
Njengoba kungekho zindlela ezintsha zokwelashwa cishe eminyakeni eyi-15, kufanele sithole izindlela ezintsha zokulwa ne-Alzheimer's. Kubalulekile ukuthi sihlole ukuthi izidakamizwa ezenzelwe ukwelapha ezinye izimo zingabasiza yini abantu abane-Alzheimer's nezinye izinhlobo zokuwohloka komqondo. Le ndlela yocwaningo ingenza kusheshe kakhulu ukuthola imithi emisha ethembisayo kubantu abayidingayo.
Ukuhlola lolu hlobo lwesixazululo, iqembu labaphenyi elibhekele ukuthuthukiswa kwale phrojekthi lisebenzise amagundane e-APP / PS1. Lolu hlobo lwamagundane we-transgenic, sikhuluma ngohlobo lwegundane eliveza izakhi zofuzo zabantu eziguqukile ezibhekene nesifo i-Alzheimer's. Phakathi kokuhlolwa okwenziwe, kufanele kuqashelwe ukuthi izilwane ezincane zelashwa ngomuthi onomsebenzi «i-agonist kathathu»Ngubani okhombisile ukuthi unayo ikhono lokuvikela ubuchopho ngezindlela ezahlukene: ukwenza ngcono ukufunda nokwakhiwa kwememori, ukuvikela amangqamuzana ezinzwa, ukunciphisa inani lamapuleti e-amyloid, ukunciphisa ukuvuvukala okungapheli nokucindezeleka okwenziwe nge-oxidative, nokunciphisa ukulahleka kwamaseli ezinzwa.
Ukwaziswa okwengeziwe: ILancaster University